"Set" - has the most definitions of any word - 464 total
"Set" has 464 definitions in the Oxford English Dictionary. "Run" runs a distant second, with 396. Rounding out the top ten are "go" with 368, "take" with 343, "stand" with 334, "get" with 289, "turn" with 288, "put" with 268, "fall" with 264, and "strike" with 250. @Curionic
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